Figure 1

Charge-Hydropathy plots. In (A) the IDP-Hydropathy scale was used, in (B) the Guy (1985) Hydropathy scale was used, and in (C) the Kyte-Doolittle (1981) hydropathy scale was used. Red circles indicate disordered proteins, blue circles indicate structured proteins. For these plots, each scale was normalized to be in the interval of 0 to 1. The Guy's scale is multiplied by -1 prior to normalization to conform to the energy rule set by Kyte-Doolittle scale. In (A) the function describing the boundary is: <charge> = 3.31 <hydropathy> -0.97. In (B) the function describing the boundary is: <charge> = 2.32 <hydropathy> -0.93. In (C), the function describing the boundary is: <charge> = 1.35 <hydropathy> -0.49.