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Table 2 The Order versus Disorder Prediction Performances of 19 Hydropathy Scales Measured by Other Metrics.

From: Improving protein order-disorder classification using charge-hydropathy plots

Scales F MCC PPV NPV
Guy 0.75 ± 0.12 0.71 ± 0.13 0.82 ± 0.10 0.94 ± 0.03
Miyazawa 0.74 ± 0.11 0.70 ± 0.12 0.80 ± 0.10 0.94 ± 0.03
Manavalan 0.74 ± 0.11 0.70 ± 0.12 0.80 ± 0.10 0.94 ± 0.03
Sweet 0.74 ± 0.08 0.71 ± 0.08 0.83 ± 0.11 0.94 ± 0.03
Fauchere 0.74 ± 0.08 0.70 ± 0.09 0.83 ± 0.12 0.94 ± 0.02
Rose 0.73 ± 0.12 0.70 ± 0.13 0.82 ± 0.09 0.94 ± 0.03
Black 0.71 ± 0.05 0.67 ± 0.06 0.81 ± 0.12 0.93 ± 0.02
Woods 0.68 ± 0.12 0.64 ± 0.13 0.78 ± 0.12 0.93 ± 0.03
Breese 0.68 ± 0.11 0.63 ± 0.13 0.75 ± 0.15 0.93 ± 0.02
Leo 0.68 ± 0.10 0.64 ± 0.12 0.79 ± 0.15 0.93 ± 0.02
Kyte-Doolittle 0.67 ± 0.13 0.63 ± 0.14 0.78 ± 0.14 0.93 ± 0.03
Roseman 0.64 ± 0.15 0.59 ± 0.17 0.75 ± 0.15 0.92 ± 0.03
Chothia 0.63 ± 0.11 0.59 ± 0.13 0.77 ± 0.15 0.92 ± 0.03
Argos 0.63 ± 0.09 0.59 ± 0.10 0.78 ± 0.13 0.92 ± 0.02
Janin 0.59 ± 0.14 0.55 ± 0.12 0.74 ± 0.11 0.91 ± 0.03
Tanford 0.57 ± 0.14 0.53 ± 0.14 0.72 ± 0.15 0.91 ± 0.02
Eisenberg 0.56 ± 0.16 0.53 ± 0.18 0.74 ± 0.20 0.91 ± 0.03
Welling 0.50 ± 0.15 0.48 ± 0.13 0.78 ± 0.19 0.89 ± 0.02
Wolfenden 0.46 ± 0.11 0.43 ± 0.13 0.69 ± 0.15 0.89 ± 0.02
  1. For equations and explanations, see the Methods section at the end of this manuscript:
  2. F: the F1 score
  3. MCC: Matthew Correlation Coefficient
  4. PPV: Positive Predictive Values
  5. NPV: Negative Predictive Values