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Table 5 IDP-Hydropathy scale performance compared to 4 disorder propensity scales, DisProt, TopIDP, FoldUnfold, and B-value.

From: Improving protein order-disorder classification using charge-hydropathy plots

Method Sens Spec Bal. acc AUC F MCC PPV NPV
IDP-Hydro 0.81 ± 0.11 0.98 ± 0.02 0.90 ± 0.07 0.94 ± 0.05 0.84 ± 0.08 0.82 ± 0.09 0.89 ± 0.09 0.96 ± 0.02
DisProt 0.77 ± 0.12 0.97 ± 0.04 0.87 ± 0.08 0.94 ± 0.06 0.80 ± 0.08 0.77 ± 0.10 0.85 ± 0.14 0.96 ± 0.02
TopIDP 0.76 ± 0.11 0.97 ± 0.02 0.87 ± 0.07 0.93 ± 0.04 0.79 ± 0.06 0.76 ± 0.06 0.84 ± 0.07 0.96 ± 0.02
FoldUnfold 0.72 ± 0.12 0.97 ± 0.02 0.85 ± 0.07 0.91 ± 0.07 0.77 ± 0.10 0.73 ± 0.11 0.82 ± 0.11 0.95 ± 0.02
Guy 0.70 ± 0.16 0.97 ± 0.02 0.84 ± 0.09 0.90 ± 0.06 0.75 ± 0.12 0.71 ± 0.13 0.82 ± 0.10 0.94 ± 0.03
B-value 0.67 ± 0.14 0.98 ± 0.02 0.83 ± 0.08 0.91 ± 0.07 0.74 ± 0.11 0.71 ± 0.12 0.85 ± 0.10 0.94 ± 0.02
Kyte-Doolittle 0.61 ± 0.16 0.96 ± 0.03 0.79 ± 0.09 0.87 ± 0.10 0.67 ± 0.13 0.63 ± 0.14 0.78 ± 0.14 0.93 ± 0.03
  1. The accuracy metrics for Guy and Kyte-Doolittle hydropathy scales are also presented as references.
  2. For equations and explanations, see the Methods section at the end of this manuscript:
  3. Sens: Sensitivity
  4. Spec: Specificity
  5. Bal. Acc: Balanced accuracy (average of sensitivity and specificity)
  6. AUC: Area under the curve
  7. F: the F1 score
  8. MCC: Matthew Correlation Coefficient
  9. PPV: Positive Predictive Values
  10. NPV: Negative Predictive Values