Mining hidden knowledge for drug safety assessment: topic modeling of LiverTox as a case study

BMC Bioinformatics

Table 1 Summary of topic model for the 26 known ALF drugs in LiverTox database.

Known ALF drugs	1^st topic		2^nd topic		3^rd topic		4^th topic
	Topic ID	Prob.	Topic ID	Prob.	Topic ID	Prob.	Topic ID	Prob.
Acetaminophen	37	4.7E-01	29	3.6E-01	4	1.4E-01	6	1.6E-02
Amoxicillin/clavulanate	37	6.3E-01	4	1.9E-01	15	1.2E-01	20	6.1E-02
Atorvastatin	31	8.3E-01	39	1.7E-01	40	3.3E-05	38	3.3E-05
Benzbromarone*	28	4.4E-01	37	4.2E-01	11	1.4E-01	40	3.8E-05
Carbamazepine	3	4.6E-01	35	3.5E-01	38	1.9E-01	40	6.7E-05
Ciprofloxacin	15	7.7E-01	14	2.3E-01	40	2.8E-05	39	2.8E-05
Cyclophosphamide	31	6.4E-01	19	2.9E-01	40	6.2E-02	39	5.2E-05
Dapsone	7	8.0E-01	31	2.0E-01	40	3.3E-05	39	3.3E-05
Diclofenac	37	8.0E-01	20	1.4E-01	23	3.3E-02	22	2.2E-02
Disulfiram	37	3.6E-01	38	2.6E-01	28	2.2E-01	7	1.6E-01
Doxycycline	37	5.9E-01	17	3.3E-01	22	7.2E-02	40	3.6E-05
Ethambutol	28	3.9E-01	10	3.5E-01	7	1.7E-01	24	8.7E-02
Halothane	23	7.1E-01	37	2.8E-01	16	6.5E-03	40	1.6E-05
Ibuprofen	31	3.2E-01	21	2.9E-01	37	2.0E-01	16	1.3E-01
Isoniazid	37	6.2E-01	23	1.2E-01	10	9.5E-02	16	6.7E-02
Methyldopa	37	7.9E-01	20	2.1E-01	40	5.2E-05	39	5.2E-05
Naproxen	37	6.2E-01	30	1.8E-01	20	1.6E-01	2	3.6E-02
Nefazodone	37	4.2E-01	26	2.7E-01	24	1.8E-01	28	1.3E-01
Nitrofurantoin	37	1.0E+00	40	4.6E-05	39	4.6E-05	38	4.6E-05
Phenytoin	7	3.0E-01	37	2.5E-01	3	2.1E-01	35	1.6E-01
Simvastatin	31	4.9E-01	37	4.4E-01	34	6.1E-02	26	1.0E-02
Sulfamethoxazole/ trimethoprim	7	8.3E-01	28	1.7E-01	40	3.5E-05	39	3.5E-05
Sulfasalazine	7	6.8E-01	37	3.2E-01	40	3.2E-05	39	3.2E-05
Tolcapone*	37	6.4E-01	25	2.7E-01	3	8.7E-02	40	3.1E-05
Troglitazone*	37	4.6E-01	31	4.2E-01	1	1.1E-01	40	2.2E-05
Valproate	35	4.2E-01	38	3.1E-01	26	2.1E-01	14	5.2E-02

ISSN: 1471-2105