Figure 5From: Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding dataTF regulatory interaction network in MCF7 cells. We proposed the SIS as a measure to compare the significance of the interaction between two TFs and constructed the TF regulatory interaction network based on the SIS scores between TFs in MCF7 cell line. The nodes represent regulatory TFs involved in interactions, and the edges represent significant interactions between TFs. The hub-TFs in MCF7 cells were E2F, E2F-1 and AP-2.Back to article page