Towards integrative gene functional similarity measurement

BMC Bioinformatics

Table 1 Illustrative example for integration similarity.

Gene Pairs	semantic Similarity			Rank of Similarity			Integration of Ranks
Gene Pairs	M _A	M _B	M _C	M _A	M _B	M _C	MAX	MIN	MEAN	MEDIAN
Gene pair 1	2.4	0.2	0.04	9	2	4	0.9	0.2	0.5	0.4
Gene pair 2	1.8	0.6	0.12	6	7	8	0.8	0.6	0.7	0.7
Gene pair 3	3.0	0.9	0.03	10	10	3	1.0	0.3	0.8	1.0
Gene pair 4	1.2	0.3	0.05	5	3	5	0.5	0.3	0.4	0.5
Gene pair 5	0.9	0.1	0.06	3	1	6	0.6	0.1	0.3	0.3
Gene pair 6	0.5	0.5	0.02	2	6	2	0.6	0.2	0.3	0.2
Gene pair 7	1.0	0.4	0.09	4	4	7	0.7	0.4	0.5	0.4
Gene pair 8	1.8	0.4	0.13	6	4	9	0.9	0.4	0.6	0.6
Gene pair 9	0.2	0.7	0.01	1	8	1	0.8	0.1	0.3	0.1
Gene pair 10	2.1	0.8	0.16	8	9	10	1.0	0.8	0.9	0.9

Illustrative example for integration similarity, where M_A, M_B and M_C are three seed gene-to-gene functional similarity measures.

ISSN: 1471-2105