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Table 1 Conditions associated with myasthenia gravis with acute exacerbation As described in the text, this table details conditions associated with the exacerbation as compared with two controls, influenza and hip joint pain, within two months of exacerbation.

From: Data-driven discovery of seasonally linked diseases from an Electronic Health Records system

ICD-9 description

Have disease (case set, 204 patients)

Incidence (case set)

Have disease (control set, 2582 patients)

Incidence (control set)

Odds ratio

p-value

Carpal tunnel syndrome

9

0.044118

2

7.75E-04

56.96

2.47E-09

Urinary tract infection site not specified

26

0.127451

76

0.029435

4.33

5.95E-09

Pneumonitis due to inhalation of food or vomitus

15

0.073529

21

0.008133

9.041

7.94E-09

Anxiety state unspecified

14

0.068627

22

0.008521

8.054

7.39E-08

Unspecified essential hypertension

53

0.259804

305

0.118125

2.199

9.73E-08

Esophageal reflux

19

0.093137

56

0.021689

4.294

8.60E-07

Unspecified pleural effusion

12

0.058824

21

0.008133

7.232

1.55E-06

Friedlander\'s bacillus infection in conditions classified elsewhere and of unspecified site

6

0.029412

2

7.75E-04

37.97

3.55E-06

Thyrotoxicosis without goiter or other cause and without thyrotoxic crisis or storm

6

0.029412

2

7.75E-04

37.97

3.55E-06

Atrial fibrillation

15

0.073529

41

0.015879

4.631

6.17E-06

Other specified disorders of pancreatic internal secretion

4

0.019608

0

0

-1

2.80E-05

Other specified idiopathic peripheral neuropathy

4

0.019608

0

0

-1

2.80E-05

Pure hypercholesterolemia

20

0.098039

83

0.032146

3.05

3.49E-05

Hemorrhage complicating a procedure

5

0.02451

2

7.75E-04

31.64

3.73E-05

Long-term (current) use of steroids

5

0.02451

3

0.001162

21.09

9.37E-05

Personal history of noncompliance with medical treatment presenting hazards to health

7

0.034314

13

0.005035

6.815

3.47E-04

Hematoma complicating a procedure

4

0.019608

2

7.75E-04

25.31

3.73E-04

Adrenal cortical steroids causing adverse effects in therapeutic use

5

0.02451

5

0.001936

12.66

3.73E-04

Nontoxic uninodular goiter

3

0.014706

0

0

-1

3.87E-04

Chronic lymphocytic thyroiditis

3

0.014706

0

0

-1

3.87E-04

Personal history of malignant neoplasm of bladder

3

0.014706

0

0

-1

3.87E-04

Personal history of malignant neoplasm of other endocrine glands and related structures

3

0.014706

0

0

-1

3.87E-04

Embolism and thrombosis of other specified veins

4

0.019608

3

0.001162

16.88

8.20E-04

Depressive disorder not elsewhere classified

14

0.068627

62

0.024012

2.858

9.55E-04

Toxic diffuse goiter without thyrotoxic crisis or storm

3

0.014706

1

3.87E-04

37.97

0.001465

Unspecified idiopathic peripheral neuropathy

3

0.014706

1

3.87E-04

37.97

0.001465

Unspecified disorder of optic nerve and visual pathways

3

0.014706

1

3.87E-04

37.97

0.001465

Personal history of tobacco use

8

0.039216

24

0.009295

4.219

0.001632

Diabetes mellitus without complication type i not stated as uncontrolled

8

0.039216

25

0.009682

4.05

0.002022

Hypertrophy (benign) of prostate without urinary obstruction

5

0.02451

9

0.003486

7.032

0.002323

Bipolar disorder, unspecified

4

0.019608

5

0.001936

10.13

0.002624

Unspecified disorder of thyroid

3

0.014706

2

7.75E-04

18.99

0.003465

Retention of urine unspecified

3

0.014706

2

7.75E-04

18.99

0.003465

Other specified retention of urine

3

0.014706

2

7.75E-04

18.99

0.003465

Migraine unspecified without mention of intractable migraine without mention of status migrainosus

4

0.019608

6

0.002324

8.438

0.004125

Other pulmonary embolism and infarction

4

0.019608

6

0.002324

8.438

0.004125

Unspecified sleep apnea

4

0.019608

6

0.002324

8.438

0.004125

Anemia unspecified

11

0.053922

53

0.020527

2.627

0.005828

Methicillin susceptible staphylococcus aureus

3

0.014706

3

0.001162

12.66

0.006558

Obstructive sleep apnea (adult)(pediatric)

3

0.014706

3

0.001162

12.66

0.006558

Tracheostomy status

4

0.019608

10

0.003873

5.063

0.015584

  1. Only the 209 patients with other conditions in the preceding two months are considered, and the number of patients with the associated condition is in the column "Have disease (case set)", with the incidence rate in the following column. The control set shown is influenza, with analagous columns. Finally the odds ratio and statistics are shown. We filter out any conditions that are directly associated with myasthenia gravis (such as shortness of breath), and also any conditions occurring in fewer than three patients with the disease.