Functional and genetic analysis of the colon cancer network

Emmert-Streib, Frank; de Matos Simoes, Ricardo; Glazko, Galina; McDade, Simon; Haibe-Kains, Benjamin; Holzinger, Andreas; Dehmer, Matthias; Campbell, Frederick Charles

doi:10.1186/1471-2105-15-S6-S6

BMC Bioinformatics

Table 2 Biological Process GPEA analysis showing the 50 most significant terms.

From: Functional and genetic analysis of the colon cancer network

GOID	GO-term	#Genes	#Interactions	p-value	GCC	CG
GO:0022403	cell cycle phase	853	938	5.8e-238	349	60/+
GO:0000278	mitotic cell cycle	776	818	7.1e-221	343	54/+
GO:0006414	translational elongation	108	156	3.0e-181	72	1
GO:0006415	translational termination	91	130	9.0e-160	67	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	105	136	4.6e-153	67	2
GO:0045047	protein targeting to ER	107	137	2.1e-152	67	2
GO:0072599	establishment of protein localization to endoplasmic reticulum	108	137	2.6e-151	67	2
GO:0006613	cotranslational protein targeting to membrane	107	136	7.4e-151	67	2
GO:0000279	M phase	537	462	4.1e-149	196	33/+
GO:0000087	M phase of mitotic cell cycle	374	321	3.6e-144	159	20/+
GO:0070972	protein localization to endoplasmic reticulum	121	140	2.2e-142	67	2
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	118	137	6.0e-141	70	2
GO:0000280	nuclear division	363	305	7.2e-138	155	20/+
GO:0007067	mitosis	363	305	7.2e-138	155	20/+
GO:0006413	translational initiation	153	155	7.4e-134	78	4
GO:0048285	organelle fission	388	318	4.0e-133	161	20/+
GO:0006412	translation	469	355	5.2e-115	183	16
GO:0000956	nuclear-transcribed mRNA catabolic process	171	150	1.1e-113	73	7
GO:0006612	protein targeting to membrane	154	139	7.9e-113	67	4
GO:0019080	viral genome expression	152	137	7.7e-112	70	10/+
GO:0019083	viral transcription	152	137	7.7e-112	70	10/+
GO:0016071	mRNA metabolic process	614	463	4.2e-109	301	21
GO:0006402	mRNA catabolic process	183	152	1.2e-107	73	7
GO:0043624	cellular protein complex disassembly	157	131	5.9e-101	67	2
GO:0043241	protein complex disassembly	162	132	9.1e-99	67	2
GO:0006401	RNA catabolic process	210	157	5.1e-96	74	7
GO:0072594	establishment of protein localization to organelle	212	156	7.8e-94	74	4
GO:0022904	respiratory electron transport chain	111	97	4.0e-90	62	5
GO:0019058	viral infectious cycle	228	158	7.2e-87	81	14/+
GO:0032984	macromolecular complex disassembly	183	133	7.8e-87	67	7
GO:0045333	cellular respiration	163	122	1.3e-86	80	9/+
GO:0006259	DNA metabolic process	880	655	2.9e-85	334	75/+
GO:0051301	cell division	480	310	2.2e-81	126	35/+
GO:0022900	electron transport chain	151	105	2.0e-74	66	5
GO:0006396	RNA processing	656	428	1.1e-73	249	18
GO:0060337	type I interferon-mediated signaling pathway	73	62	3.2e-67	29	5
GO:0071357	cellular response to type I interferon	73	62	3.2e-67	29	5
GO:0034340	response to type I interferon	74	62	1.7e-66	29	5
GO:0002682	regulation of immune system process	893	609	1.2e-63	265	83/+
GO:0051320	S phase	148	89	2.7e-58	40	8
GO:0045087	innate immune response	544	308	1.8e-56	151	25/+
GO:0051325	interphase	405	218	8.8e-56	116	34/+
GO:0022411	cellular component disassembly	295	156	3.7e-55	69	12
GO:0016032	viral reproduction	701	419	1.5e-54	150	46/+
GO:0044764	multi-organism cellular process	703	420	2.5e-54	150	46/+
GO:0022415	viral reproductive process	547	305	4.6e-54	107	44/+
GO:0051329	interphase of mitotic cell cycle	399	210	3.8e-53	114	34/+
GO:0050776	regulation of immune response	564	313	2.2e-52	146	43/+
GO:0030198	extracellular matrix organization	209	110	5.5e-52	54	11/+
GO:0043062	extracellular structure organization	210	110	1.4e-51	54	11/+

Significant enrichment of cancer census genes is indicated by a '+' (column seven). GCC denotes the size of the giant connected component corresponding to the genes of a GO-term; CG number of census cancer genes in the GCC.

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ISSN: 1471-2105

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