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Table 3 The 10 major hub genes of the colon cancer network.

From: Functional and genetic analysis of the colon cancer network

entrez

symbol

Description

degree

locus

most significant GO-term

81137

OR7E104P

olfactory receptor

458

chr13q21.31

GO:0007268 synaptic transmission

2623

GATA1

transcription factor

321

chrXp11.23

GO:0007601 visual perception

348808

NPHP3-AS1

antisense RNA

262

chr3q22.1

GO:0050906 detection of stimulus involved in sensory perception

285877

POM121L12

transmembrane protein

247

chr7p12.1

GO:0007606 sensory perception of chemical stimulus

283933

ZNF843

zinc finger protein

231

chr16p11.2

GO:0030534 adult behavior

60506

NYX

extracellular matrix

217

chrXp11.4

GO:0042749 regulation of circadian sleep/wake cycle

387601

SLC22A25

anion transporter

216

chr11q12.3

GO:0048511 rhythmic process

284805

C20orf203

ORF

212

chr20q11.21

GO:0006813 potassium ion transport

6521

SLC4A1

anion transporter

208

chr17q21.31

GO:0072529 pyrimidine-containing compound catabolic process

163778

SPRR4

envelope precursor

207

chr1q21.3

GO:0007608 sensory perception of smell

  1. The hub genes are described by their entrez gene id, gene symbol, short description, node degree, chromosomal location and the most significant GO-term based on a Gene Ontology enrichment analysis based on the direct interactions for each hub gene.