Structure prediction of polyglutamine disease proteins: comparison of methods

BMC Bioinformatics

Table 1 Length of poly-Qs in polyglutamine diseases.

	Gene	Wild-type allele repeat number	Mutant allele repeat number
SCA1	ATXN1	6-39	41-83
SCA2	ATXN2	13-31	> = 32
SCA3	ATXN3	12-43	60-89
SCA6	CACNA1A	<18	20-33
SCA7	ATXN7	<19	36-460
SCA8	ATXN8	15-50^a	80-250^a
SCA17	TBP	25-42	49-66
HD	HTT	10-26	>40
DRPLA	ATN1	6-35	>48
SBMA	AR	< =36	>38

^a The non-coding gene ATXN8OS gene may contribute to SCA8 pathogenesis. The number of CAG repeats in normal and mutant ATXN8 are assumed to be the same as the number of CTG repeats in normal and mutant ATXN8OS, as in [4].

ISSN: 1471-2105