Table 2 Transitions of the model [4]
Symbol | Transition Name | Biological Event |
|---|---|---|
t1 | MATalpha_cell(surroundings) | MATα cell secretes its mating pheromone |
t2 | binding_factor_to_receptor | α-factor binds to the Ste2 receptor |
t3 | receptor_synthesis | synthesis of the cell surface Sst2 |
t4 | receptor_conformation_change | conformation change of the receptor |
t5 | division(in_alpha_subunit:GDP)→ GTP | dissociation of the Gα subunit of the G-protein |
t6 | hydrolysis_GTP→ GDP | hydrolysis reassociates Gα with Gβγ |
t7 | interact_through_Far1 | Gβγ interacts Far1 transmitted with Cdc24 |
t8 | Cdc42:GDP→ GTP | Cdc24 activates Cdc42 |
t9 | active_Cdc42_constitutive_at_pm | constitute active Cdc42 attending the processes |
t10 | Ste20_input | source of Ste20 |
t11 | Ste20_activated | Cdc42 at plasma membrane and Bem1 activates Ste20 |
t12 | Ste5_input | source of Ste5 |
t13 | Ste5_binds_Ste11 | Ste5 binds Ste11 |
t14 | Fus3_synth | synthesis of kinase Fus3 |
t15 | Fus3_binds_Ste7 | Ste7 binds Fus3 |
t16 | complex-formation | Ste5/Ste11 binds Ste7/Fus3 |
t17 | Ste20_phos_Ste11 | phosphorylation of Ste11 by Ste20 |
t18 | Ste11_phos_Ste7 | phosphorylation of Ste7 by Ste11 |
t19 | Ste7_phos_Fus3 | phosphorylation of Fus3 by Ste7 |
t20 | Fus3PP-release | release of activation Fus3 out of the MAPK complex |
t21 | binding_free_Fus3 | remaining MAPK complex binds Fus3 |
t22 | Ste12_inhibit_phos | phosphorylation of Ste12 inhibitors Dig1/Dig2 by Fus3PP |
t23 | Ste12-release | release of Ste12 out of the repression complex |
t24 | Ste12_phos | phosphorylation of Ste12 by Fus3PP |
t25 | transcr_activation | transcription activation of pheromone regulated genes |
t26 | Fus3PP_dephos | dephosphorylation of Fus3PP by Msg5 |
t27 | repression_through_Fus3 | Ste12 repression through inactive Fus3 and Dig1/Dig2 |
t28 | cell_fusion | processes leading to the fusion of the two haploid cells |
t29 | transport_out_of_cell | Bar1 transport into the cell environment |
t30 | factor_destruction | Bar1 transmitted destruction of the α-factor |
t31 | Far1_phos | phosphorylation of Far1 by Fus3PP |
t32 | cell_cycle_arrest_in_G1 | Far1 caused arrest in the cell cycle phase G1 |
t33 | transport_out_of_cell | Bar1 transport into the cell environment |
t34 | Sst2_phos | phosphorylation of Far1 by Fus3PP |
t35 | transport_out_of_nucleus | Sst2 transport out of the nucleus |
t36 | accelerated_hydr_GTP→ GDP | accelerated hydrolysis reassociates the G-protein |
t37 | Ste11_neg_phos | Fus3PP labels the MAPK complex at Ste11 for degradation |
t38 | degradation | degradation of the MAPK complex |
t39 | Ste7_neg_phos | Fus3PP labels the MAPK complex at Ste7 for degradation |
t40 | Ste7_phos_Kss1 | phosphorylation of Kss1 by Ste7 |
t41 | accelerated-dephos-Kss1 | deactivation of phosphorylation Kss1 by Fus3PP |
t42 | Kss1_dephos | dephosphorylation of phosphorylated Kss1 by Msg5 |
t43 | repression_through_Kss1 | Ste12 repression through inactive Kss1 by Msg5 |
t44 | tech_input | techinal:the repressed Ste12 complex assumed to be present |
t45 | Akr_synthesis | synthesis of Akr1 |
t46 | Akr1_binds_Yck1/Yck2 | Akr1 binds Yck1/Yck2 |
t47 | receptor_phos | labelling of Ste2 for degradation |
t48 | ubiquit_endocytosis | ubiquitination and endocytosis of the receptor |