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Table 1 Graphical lasso algorithm.

From: Inference of radio-responsive gene regulatory networks using the graphical lasso algorithm

1. Initialize W = S + λI. Note that the diagonal of W is fixed in what follows.

2. Repeat the following steps until W is converged.

   a. Partition the matrix W such that the target column is last.

   b. Solve the lasso problem using the coordinate descent algorithm.

   c. Update w 12 = W 11 β .

3. In the final cycle, calculate

θ 12 = - β θ 22 with θ 22 =1/ ( w 22 - w 12 T β ) .