This diagram illustrates an iterative adaption of an existing 'low-density' design, to the high-density encoding adopted by BactoGeNIE. At the top, we showed existing 'low-density' orthology-line and text-label encodings. The first transformation, shown by the arrow, reduces the number of pixels for each genome and the gap between genomes, which results in visual clutter. Visual clutter is reduced by replacing lines with color to encode orthology. Finally, by removing text labels BactoGeNIE produces a high-density encoding suitable for large-scale comparative tasks.