Figure 3
From: Integrated visual analysis of protein structures, sequences, and feature data
Structures and features for human BLK protein. (A) BLK contains three independently evolved sequence domains, each with its own function. By mapping the UniProt "domain" feature set (B) onto the structure automatically selected by Aquaria, the user is able to clearly see which parts of the structure correspond to which domain. (C) The Matching Structure panel shows that there is no PDB structure exactly matching the BLK sequence, while many (over 3,000) related structures exist, thus providing a wealth of detail on the molecular processes of related proteins. Most of the related structures match to the kinase domain; many match to either the SH2 or SH3 domain, while a small number contain all three domains in the same order as BLK.