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Figure 6 | BMC Bioinformatics

Figure 6

From: Global multiple protein-protein interaction network alignment by combining pairwise network alignments

Figure 6

SMAL based on NETAL. The y-axis shows the number of interactions conserved in at least 3 species in a MNA. Each bar represents the value of this measure achieved by a MNA computed with a specific algorithm abbreviated as: IR - IsoRankN, SM - SMETANA, PI - PINALOG, NT - NETAL. SMAL MNAs based on NETAL achieve by far the highest scores. (Top) is a MNA with Human as the scaffold. (Bottom) is the same measure for MNAs using Drosophila as scaffold. While overall less interactions are conserved in at least 3 species when using Drosophila, SMAL based on NETAL again outperforms all other algorithms with SMAL based on PINALOG consistently ranking second. The native MNA implementations (available only for SMETANA and IsoRankN) as well as their SMAL counterparts achieve much lower scores. These results show that SMAL allows for creation of MNAs based on pairwise algorithms that outperform existing native MNA algorithms for specific applications or measures.

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