Global multiple protein-protein interaction network alignment by combining pairwise network alignments

BMC Bioinformatics

Table 5 Precision in SMAL and native MNA implementations

NForH	IsoRankN	SMETANA	IsoRankN	SMETANA	IsoRankN	SMETANA	IsoRankN	SMETANA
Relative change in precision	Droso	Droso	Human	Human	Mouse	Mouse	Yeast	Yeast
4-species	-5.82%	-11.13%	-10.21%	-3.74%	-6.44%	-2.03%	NA	NA
5-species	8.24%	-13.41%	-1.20%	-9.97%	-6.67%	-7.83%	-21.59%	0.24%
6-species	9.27%	-13.67%	1.89%	-12.02%	-2.74%	-10.39%	-21.83%	-1.79%
7-species	5.07%	-13.99%	2.79%	-9.50%	-0.34%	-9.86%	-24.33%	-1.52%
8-species	-5.05%	1211.83%	-4.18%	1239.56%	-1.17%	1534.16%	-24.44%	1697.95%

Comparison of alignment precision with regards to the NForH measure as expressed by Equation (26). Values represent the relative change in precision using the native implementation as the reference according to Equation (27). Positive values in the table correspond to alignments where SMAL was more precise than the native implementation. Negative values appear when SMAL was less precise. Since Yeast was not part of the 4-species MNA, no value is presented in the respective cells.

ISSN: 1471-2105