Table 2 Top 20 novel drug repositioning candidate identified and the count of PubMed publication support the proposed clinical indications
From: DMAP: a connectivity map database to enable identification of novel drug repositioning candidates
Drug | Disease | PubMed (Clinical) |
|---|---|---|
Rocuronium | Pain | 126 |
Clemastine | Allergies | 80 |
Mometasone | Asthma | 78 |
Nicotinamide | Alzheimer Disease | 45 |
Sotalol | Hypertension | 42 |
Sertraline | Alzheimer Disease | 40 |
Ifosfamide | Leukemia, Acute Myeloid | 40 |
Gabapentin | Anxiety disorder | 33 |
Vinorelbine | Prostate Cancer | 32 |
Lumiracoxib | Pain | 28 |
Hydrocodone | Anesthetic | 25 |
Zileuton | Inflammatory diseases | 20 |
Irbesartan | Cardiovascular disease | 17 |
Moclobemide | Parkinson Disease | 13 |
Fluvoxamine | Alzheimer Disease | 10 |
Ranolazine | Dysrhythmias | 6 |
Trihexyphenidyl | Depression | 5 |
Nicotinamide | Breast Cancer | 5 |
Methylphenidate | Obesity | 5 |
Pemetrexed | Colon cancers | 1 |