DNA and RNA-based mutational dynamics and clonal evolution. The temporal variant dynamics and clonal evolution of key genes across the Presentation (blue) and Relapse (grey) samples are illustrated. Subfigure A illustrates DNA level mutational dynamics and B, mRNA expressed mutations. Information regarding the year each sample was obtained, total number of mutations (N), computed Shannon Diversity Index (SDI), and the number of key genes (KG) are provided for each sample. Key genes identified within each sample are listed. An arc from a gene symbol into another sample indicates the survival of the mutation through the selection event (definitive therapy). Non-surviving key gene (as well as passengers) mutations are listed.