Maguk PDZ event history. Based on reconciled domain tree 84, shown in Fig. S2 (in Additional File 1). Leaf labels correspond to protein name, followed by domain name. Domains in each protein are numbered in N- to C-terminal order. Clades containing mouse, human, and chicken orthologs are collapsed, except in the Carmafamily, in which orthologous sequences are not monophyletic. Clades of paralogous genes from the same subfamily are also collapsed. All insertion events that are not within collapsed clades are shown (yellow arrows, annotated with event support values), including seven of the nine high-scoring events. Domain losses are indicated in gray. Gene losses not shown.