Table 4 Amino acid composition (AAC) of high binding affinity (HBA) and low binding affinity (LBA) complexes and three physicochemical properties.
Amino acid | HBA_AAC (%) | LBA_AAC (%) | Composition difference (%) | aGUYH850105 | bSNEP660104 | cCHOP780101 |
|---|---|---|---|---|---|---|
Ala | 7 | 6.8 | 0.2 | -0.27 | -0.062 | 0.66 |
Arg | 4.2 | 4.8 | -0.6 | 2 | -0.167 | 0.95 |
Asn | 4.8 | 4.5 | 0.3 | 0.61 | 0.166 | 1.56 |
Asp | 5.2 | 5.9 | -0.7 | 0.5 | -0.079 | 1.46 |
Cys | 2.6 | 1.7 | 0.9 | -0.23 | 0.38 | 1.19 |
Glu | 3.9 | 4.2 | -0.3 | 1 | -0.025 | 0.98 |
Gln | 5.7 | 7 | -1.3 | 0.33 | -0.184 | 0.74 |
Gly | 7.8 | 6.6 | 1.2 | -0.22 | -0.017 | 1.56 |
His | 2.1 | 2.3 | -0.2 | 0.37 | 0.056 | 0.95 |
Ile | 4.7 | 5.3 | -0.6 | -0.8 | -0.309 | 0.47 |
Leu | 8.2 | 9 | -0.8 | -0.44 | -0.264 | 0.59 |
Lys | 5.7 | 6.4 | -0.7 | 1.17 | -0.371 | 1.01 |
Met | 1.7 | 2.3 | -0.6 | -0.31 | 0.077 | 0.6 |
Phe | 3.5 | 4 | -0.5 | -0.55 | 0.074 | 0.6 |
Pro | 4.9 | 4.7 | 0.2 | 0.36 | -0.036 | 1.52 |
Ser | 8.6 | 6.7 | 1.9 | 0.17 | 0.47 | 1.43 |
Thr | 6.7 | 6 | 0.7 | 0.18 | 0.348 | 0.96 |
Trp | 1.7 | 1.4 | 0.3 | 0.05 | 0.05 | 0.96 |
Tyr | 3.9 | 3.5 | 0.4 | 0.48 | 0.22 | 1.14 |
Val | 7 | 6.9 | 0.1 | -0.65 | -0.212 | 0.5 |