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Table 4 Amino acid composition (AAC) of high binding affinity (HBA) and low binding affinity (LBA) complexes and three physicochemical properties.

From: Characterizing informative sequence descriptors and predicting binding affinities of heterodimeric protein complexes

Amino acid HBA_AAC (%) LBA_AAC (%) Composition difference (%) aGUYH850105 bSNEP660104 cCHOP780101
Ala 7 6.8 0.2 -0.27 -0.062 0.66
Arg 4.2 4.8 -0.6 2 -0.167 0.95
Asn 4.8 4.5 0.3 0.61 0.166 1.56
Asp 5.2 5.9 -0.7 0.5 -0.079 1.46
Cys 2.6 1.7 0.9 -0.23 0.38 1.19
Glu 3.9 4.2 -0.3 1 -0.025 0.98
Gln 5.7 7 -1.3 0.33 -0.184 0.74
Gly 7.8 6.6 1.2 -0.22 -0.017 1.56
His 2.1 2.3 -0.2 0.37 0.056 0.95
Ile 4.7 5.3 -0.6 -0.8 -0.309 0.47
Leu 8.2 9 -0.8 -0.44 -0.264 0.59
Lys 5.7 6.4 -0.7 1.17 -0.371 1.01
Met 1.7 2.3 -0.6 -0.31 0.077 0.6
Phe 3.5 4 -0.5 -0.55 0.074 0.6
Pro 4.9 4.7 0.2 0.36 -0.036 1.52
Ser 8.6 6.7 1.9 0.17 0.47 1.43
Thr 6.7 6 0.7 0.18 0.348 0.96
Trp 1.7 1.4 0.3 0.05 0.05 0.96
Tyr 3.9 3.5 0.4 0.48 0.22 1.14
Val 7 6.9 0.1 -0.65 -0.212 0.5
  1. aGUYH850105 = Apparent partition energies.
  2. bSNEP660104 = Principal component analysis IV.
  3. cCHOP780101 = Normalized frequencies of beta turn.