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Figure 1 | BMC Bioinformatics

Figure 1

From: Tetranucleotide usage in mycobacteriophage genomes: alignment-free methods to cluster phage and infer evolutionary relationships

Figure 1

A) Neighbor joining tree constructed from tetranucleotide usage deviation distances and B) tree from [4] constructed from predicted protein products in a subset of sequenced mycobacteriophages. Our method accurately places phage in a monophyletic clade with members of the same subcluster and often reconstructs relationships between subclusters. In some cases, a subcluster is not placed with other members of the cluster because of significant and conserved differences in tetranucleotide usage, such as overrepresentation of the 4-mer 'GATC' in cluster B3 genomes.

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