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Table 1 Summary of GWA studies, disease genes, SNPs, drugs, and target genes for five disease categories

From: A comparative study of disease genes and drug targets in the human protein interactome

Disease category GWAS Gene SNP Drug Target Overlapa P-valueb ATC codec
Cancer 147 326 341 115 171 7 0.01 L01
Cardiovascular 52 177 202 230 273 5 0.06 C
Immune 92 328 398 49 70 8 1.3 × 10-5 L03, L04
Metabolic 90 601 561 146 185 13 2.0 × 10-3 A02, A03, A04, A05, A06, A07, A10
Nervous 74 162 178 314 248 3 0.18 N
Total 450 1,344 1,586 827 719 95 1.6 × 10-11  
  1. aThe number of common genes between disease genes and drug target genes for each disease category.
  2. bThe P-value was calculated by hypergeometric test on the common genes between disease genes and target genes compared with the human protein-coding genes for each disease category. cThe detail information for each ATC code was included in the Materials and methods.