A comparative study of disease genes and drug targets in the human protein interactome

BMC Bioinformatics

Table 1 Summary of GWA studies, disease genes, SNPs, drugs, and target genes for five disease categories

Disease category	GWAS	Gene	SNP	Drug	Target	Overlap^a	P-value^b	ATC code^c
Cancer	147	326	341	115	171	7	0.01	L01
Cardiovascular	52	177	202	230	273	5	0.06	C
Immune	92	328	398	49	70	8	1.3 × 10^-5	L03, L04
Metabolic	90	601	561	146	185	13	2.0 × 10^-3	A02, A03, A04, A05, A06, A07, A10
Nervous	74	162	178	314	248	3	0.18	N
Total	450	1,344	1,586	827	719	95	1.6 × 10^-11

^aThe number of common genes between disease genes and drug target genes for each disease category.
^bThe P-value was calculated by hypergeometric test on the common genes between disease genes and target genes compared with the human protein-coding genes for each disease category. ^cThe detail information for each ATC code was included in the Materials and methods.

ISSN: 1471-2105