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Table 3 Summary of one-sided Wilcoxon tests' P-values comparing the disease/target fraction in the target/disease neighbor with those of the randomized nodes at first-degree, second-degree, and third degree

From: A comparative study of disease genes and drug targets in the human protein interactome

Degree First-degree Second-degree Third-degree
Disease neighborhood   
Cancer 2.37 × 10-6 7.68 × 10-15 2.94 × 10-9
Cardiovascular 4.67 × 10-4 1.56 × 10-41 2.33 × 10-54
Immune 0.04 1.28 × 10-4 8.12 × 10-5
Metabolic 0.72 0.08 0.99
Nervous 0.70 0.46 0.92
Target neighborhood   
Cancer 2.82 × 10-14 4.67 × 10-20 4.76 × 10-11
Cardiovascular 0.01 2.24 × 10-43 3.62 × 10-70
Immune 1.48 × 10-13 1.13 × 10-7 0.01
Metabolic 5.00 × 10-5 0.08 0.60
Nervous 0.84 0.71 0.35