Figure 1
From: Identifying overlapping mutated driver pathways by constructing gene networks in cancer
The illustration process of the mutated driver pathways identification problem is shown in the figure. A) Somatic mutation data in multiple patients are represented in a mutation matrix. B) Calculate the exclusive degree between each pair of genes, and construct a gene interaction network according to the exclusive degree. If the exclusive degree between the pair of genes is greater than or equal to λ, an edge is created between the two genes and the exclusive degree is represented as its weight. C) The exclusive degree of Set 1 is 1 and its coverage degree is also 1. If g4 is combined to Set 1, the exclusive degree of Set 1 will be reduced. The exclusive degree of Set 2 is 0.9 and the coverage degree of that is 1. If g4 is combined to Set 2, the exclusivity of Set 2 will be reduced.