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Figure 4 | BMC Bioinformatics

Figure 4

From: Psychoactive pharmaceuticals as environmental contaminants may disrupt highly inter-connected nodes in an Autism-associated protein-protein interaction network

Figure 4

PPCP MIX (CBZ, VNX, FLX) and Valproate (VPA) - enriched gene sets were more inter-connected than the overall network. This figure compares network characteristics of gene sets enhanced by a mixture of pharmaceuticals (CBZ, VNX, FLX) and valproate (VPA) in human cell cultures. Bars are pseudomedians (i.e., Hodges-Lehman estimators of location) whiskers are bootstrap standard errors of pseudomedians. Location measures with the same letter are not significantly different, using the BDM rank-based permutation procedure, after Holm's adjustment for simultaneous inference. Gray dashed horizontal lines are the pseudomedian values for the complete ASD network. Gray stars indicate that the treatment locations are significantly greater than the complete network pseudomedian using Wilcoxon one-sample rank sum tests.

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