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Table 3 Number of target genes that must be returned by each database, in order to retrieve (cover) a given percentage of validated interactions coming from miRTarBase and involving hsa-mir-17 and hsa-mir-20a, respectively.

From: ComiRNet: a web-based system for the analysis of miRNA-gene regulatory networks

  

Covered %

 

Database

No. Interactions

10%

20%

30%

40%

50%

60%

70%

AUPRC

Diana-micro T

4106

359

1010

1999

-

-

-

-

0.0252

microCosm

1197

-

-

-

-

-

-

-

0.0010

picTar 4-way

0

-

-

-

-

-

-

-

0.0000

picTar 5-way

0

-

-

-

-

-

-

-

0.0000

PITA All Targets

8027

431

1373

2860

4710

6776

-

-

0.0233

PITA Top Targets

859

349

-

-

-

-

-

-

0.0157

TargetScan C

991

538

890

-

-

-

-

-

0.0135

TargetScan NC

2954

1250

2507

-

-

-

-

-

0.0057

Miranda

2336

920

1687

-

-

-

-

-

0.0087

RNA22 3' UTR

0

-

-

-

-

-

-

-

0.0000

mirDIP

20470

669

1813

3455

5653

9821

-

-

0.0173

TarMir

6759

564

1186

2562

4175

6464

-

-

0.0216

ComiRNet

9218

32

623

1647

4500

7854

-

-

0.1664

  

Covered %

 

Database

No. Interactions

10%

20%

30%

40%

50%

60%

70%

AUPRC

Diana-micro T

3857

326

798

1608

3789

-

-

-

0.0170

microCosm

1029

-

-

-

-

-

-

-

0.0008

picTar 4-way

610

278

-

-

-

-

-

-

0.0122

picTar 5-way

268

-

-

-

-

-

-

-

0.0040

PITA All Targets

8027

940

2095

3602

5035

6600

-

-

0.0090

PITA Top Targets

859

390

-

-

-

-

-

-

0.0087

TargetScan C

990

466

869

-

-

-

-

-

0.0083

TargetScan NC

2954

957

2389

-

-

-

-

-

0.0039

Miranda

2499

536

1410

-

-

-

-

-

0.0085

RNA22 3' UTR

1640

1153

-

-

-

-

-

-

0.0022

mirDIP

23873

493

1367

2861

5658

8755

12834

-

0.0130

TarMir

5963

427

1165

2108

3831

-

-

-

0.0142

ComiRNet

9879

18

599

1540

3983

6900

9524

-

0.1624

  1. No. Interactions is the total number of interactions in a given database which involve the specified miRNA. The symbol "-" indicates that the database does not contain the specified percentage of interactions of miRTarBase. AUPRC is the area under the precision-recall curves (i.e. the area under the lines in Figures 5 and 6).