Mapping the HMM histogram to the crystal structure of parvalbumin B. A) The HMM histogram mapped onto the crystal structure (PDB code: 1CDP) of parvalbumin B. Using the same conventions as Fig. 5A, the Ca2+ binding loops of two EF-hand motifs have a high occurrence level. B) The HMM histogram of the parvalbumin B subfamily with an e-value cutoff of 0.1. The orange regions in the histogram reflect the segments encoding the Ca2+ binding loops. Below the histogram is the domain layout. The blue rectangle represents the EF-hand motif (EF). C) The MSA of the parvalbumin B subfamily. Using the same conventions as Fig. 5C, the Ca2+ binding loops are highlighted orange.