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Figure 2 | BMC Bioinformatics

Figure 2

From: The limit fold change model: A practical approach for selecting differentially expressed genes from microarray data

Figure 2

Schematic representation of the cyclical nature of the limit fold change (LFC) model. Selecting an initial X% LFC model (1) provides a starting point for the identification of those genes differentially regulated. Genes can then be ranked (2) by a calculation combining fold change and absolute expression in order to assign a degree of importance. Validation of the chosen LFC model by a complementary technique such as RT-PCR (3) and/or the characterization of variance (4) enables the analyst to reexamine the initial LFC model and determine the confidence level for the results. Depending on the data set, one could redefine the LFC model and repeat the cycle.

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BMC Bioinformatics

ISSN: 1471-2105

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