Figure 2

APE1 Molegos near the DNA. The structures for the motifs of Table 1 are taken from a minimized 1DE8 crystal structure of APE1 bound to an uncleaved 11mer DNA with an abasic site. One Mg²⁺ ion was inserted at the position seen in the 1DE9 minimized structure based on 1DE8 (huAPE1/Mg²⁺/11 bp (cleaved) AP-containing oligonucleotide). The molegos contain residues bind to DNA and have corresponding molegos in other proteins identified in the PSIBLAST search.