Figure 4

APE Motifs common to DNase-1 and Synaptojanin have similar structure. Conserved areas of huAPE1 (from PDB file 1DE9) form the β-barrel core (left side). The motifs common to DNase1 (1DNK) and Synaptojanin (1I9Z) form a similar catalytic site, with the substrate (from the appropriate structure file) directed to the top of the β-strands and the metal ion binding site. The strands in the middle and right figures are colored according to their identity (green) or similarity (blue) to APE1. Residues that differ are red, the insertions needed for correct alignment in synaptojanin are yellow.