Figure 5

Protein DNA contact plots for huAPE1. Protein/DNA contact plots for huAPE1 binding to substrate DNA taken from the minimized IDE8 structure described in Figure 2. Blocks, black at 1.5 Å, lighten with increasing distance of residues from the DNA up to 7.5 Å. Most of the MASIA motifs (Table 1) for the APE family are near the DNA interface. The motifs are indicated by numbers; the abasic site at position 6 is indicated by arrows.