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Figure 6 | BMC Bioinformatics

Figure 6

From: Sources of variability and effect of experimental approach on expression profiling data interpretation

Figure 6

Use of >2-fold survival method provides relatively specific, but insensitive detection of significant gene changes. Shown in green is a representation of number of genes surviving four pair-wise comparisons to two mixed control profiles, with retention of only those genes showing fold changes > 2-fold in the four pair-wise comparisons. Shown in red are differentially expressed genes for 10 individual DMD 5–6 y profiles versus 6 mixed controls at the indicated p-value thresholds. This fold-change survival method shows good specificity at p < 0.05 for individual profiles (85%), however it is relatively insensitive.

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