Architecture of LAD deployment. LAD is accessed exclusively through a web browser. Additionally, it relies completely on the open-source technologies Linux and PostgreSQL for operation. Organism annotations are kept up to date via a scripted linkage to external databases. The Saccharomyces Genome Database (SGD – http://www.yeastgenome.org) and the National Center for Biotechnology Information (NCBI – http://www.ncbi.nlm.nih.gov/) are shown as examples.