Figure 3

Number of superfamily-superfamily interactions observed using different residue-residue contact count and residue contact distance thresholds to analyse domain-domain contacts in the PDB. Below four Angstroms almost all superfamilies are 'isolated' from the interaction network, making very few residue-residue contacts with other superfamilies at this range. At four Angstroms, the number of interactions observed is critically dependant on the number of residue contacts threshold used, while at five Angstroms the contact count threshold has less effect.