Table 2 Selection of genes identified using CIA

F1 (mesenchymal)

All CNS, Renal cells and the breast cancer cell line BR-Hs578T

COL1A1

Collagen marker

-

+

COL4A1

Collagen marker

+

-

COL4A2

Collagen marker

-

+

TPM1

Muscle marker

-

+

VIM

Vimentin

-

+

FN1

Fibronectin 1

+

+

TGF β

Inducer of EMT

-

+

CDH2

N-cadherin

+

-

MT2A

Metallothionein A2-associated with invasive breast cancer

-

+

F1 (epithelial)

All colon cells and the breast cancer cells MCF-7 and TR7D

CDH1

E-cadherin, primary epithelial marker

+

-

SPINT2

Serine protease inhibitor, Kunitz type, 2 an inhibitor of hepatocyte growth factor

+

+

KRT8

Keratin 8, epithelial marker

+

+

KRT18

Keratin 18, epithelial marker

-

+

KRT19

Keratin 19, epithelial marker

-

+

DSP

Desmoplakin I, epithelial marker

+

-

S100A2

Loss of S100A2 early event in melanoma development

-

+

F1 (colon cell markers)

TACSTD1

Ep-Cam. Target antigen in colorectal carcinoma

+

+

CDKN2A

Target antigen in colorectal carcinoma

+

-

F1 (Leukaemia)

All leukaemia cell lines

ARHGDIB

A lymphoid-specific guanosine diphosphate dissociation inhibitor

+

+

LCP1

Lymphocyte cytosolic protein 1, L-plastin

+

-

IFITM1

An interferon induced transmembrane protein

-

+

F2 (Melanoma)

All melanoma cells and the breast cancer cells BR_MDA and BR_MDAMB435

MITF

Microphthalamia-associated transcription factor

-

+

TYR

Tyrosinase

-

+

DCT

Dopachrome tautomerase

-

+

TYRP1

Tyrosinase-related protein 1

-

+

RAB7

Ras-associated protein 7

-

+

MIA

Melanoma inhibitory activity

-

+

MCAM

MUC18, melanoma cell adhesion molecule MCAM

+

-

MAGE 3

Melanoma-associated antigen 3

-

+

MAGE 12

Melanoma-associated antigen 12

-

+

GPNMB

Glycomembrane protein nmb

-

+

TIMP2

Tissue inhibitor of metalloproteinase 2

-

+

TIMP3

Tissue inhibitor of metalloproteinase 3

+

-