Table 3 Predicted function/contacts of conserved residues. Homologous residues making similar contacts in different structures are in the same rows. Interacting functional groups are indicated in parentheses ("b" denotes backbone). Contacts absent from the lowest-energy solution, but present in other "top 20" solutions are shown in italics.
| Â | Structure: | 1gz0 | 1ipa | 1k3r |
|---|---|---|---|---|
a) AdoMet-binding | adenine | A175 | T194 | S190 |
| Â | Â | G201 | G220 | G223 |
| Â | ribose O2 | M202 (bNH) | L221(bNH) | L224(bNH) |
| Â | ribose O3 | G196(bNH) | G215(bNH) | G218(bNH) |
| Â | Â | T174(OH) | T193(bCO) | T189(bCO) |
| Â | methionine COO - | I216(bNH) | I235(bNH) | L236(bNH) |
| Â | Â | Â | Â | T235(bNH) |
| Â | methionine NH 3 + | I216(bCO) | I235(bCO) | Â |
| Â | Â | Â | Â | N234(OD1) |
| Â | Â | Â | Â | Q239(OE1) |
b) target binding & catalysis | (precise role unknown) | N108 | N129 | K27 |
| Â | Â | E198 | E217 | P220 |
| Â | Â | S224 | S243 | T243 |
| Â | Â | N226 | N245 | R245 |
| Â | Â | Â | Â | T246 |
| Â | Â | S228 | S247 | E247 |
| Â | Â | R114 (2nd subunit) | R135 (2nd subunit) | R33 (2nd subunit) |