Skip to main content

Table 1 Classifying the HotDog superfamily into subfamilies.

From: The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases

Number of Members

Phyletic distribution

Subfamily Name

Representative member(s)

Accession Number

E.C. number

Associated Domain(s)

General Function

135

Proteobacteria : 67

Acyl-CoA thioesterases

Cytosolic long-chain acyl-CoA thioester hydrolase/ Brain acyl-CoA hydrolase

Q64559

3.1.2.2

2 × HotDog

Fatty acid metabolism

 

Metazoa: 25

      
 

Firmicutes: 16

      
 

Archaea: 9

      
 

Actinobacteria: 7

 

Cytoplasmic acetyl-CoA hydrolase (including brown fat inducible thioesterase)

Q8WYK0

3.1.2.1

2 × HotDog, START

Fatty acid metabolism

 

Chlamydiae: 4

      
 

Viridiplantae: 2

      
 

Fungi: 2

      
 

Deinococcus-Thermus: 2

 

Acyl-CoA hydrolase

Q81EE4

3.1.2.20

None

Fatty acid metabolism

 

Chlorobi: 2

 

Probable medium chain acyl-CoA hydrolase

Q7NUH6

3.1.2.19

None

Fatty acid metabolism

130

Proteobacteria: 61

FabZ-like Dehydratases

(3R)-hydroxymyristoyl – (acyl-carrier-protein) dehydratase/ β-hydroxy-acyl ACP dehydratase (FabZ)

P94584

4.2.1.58

Lpx C in Q8KBX0

Fatty acid biosynthesis, lipid A biosynthesis (Q8KBX0)

 

Firmicutes: 36

      
 

Cyanobacteria: 9

      
 

Chlamydiae: 4

 

Coronafacic acid (CFA) dehydratase

P72238

4.2.1-

None

CFA biosynthesis

 

Alveolata: 4

      
 

Viridiplantae: 4

      
 

Planctomycetes: 3

      
 

Bacteroidetes: 2

      
 

Fusobacteria: 2

      
 

Aquificae: 1

      
 

Chlorobi: 1

      
 

Deinococcus-Thermus: 1

      
 

Metazoa: 1

      
 

Thermotogae: 1

      

122

Proteobacteria: 81

MaoC dehydratase-like

(R) specific enoyl-CoA hydratase (phaJ)

Q8KRE2

4.2.1.-

None

PHA biosynthesis

 

Firmicutes: 13

 

PHA synthase (phaC)

O32472

   
 

Archaea: 11

 

MaoC protein

P77455

 

None

PHA biosynthesis

 

Actinobacteria: 8

 

17-beta-hydroxysteroid dehydrogenase

P51659

 

Aldehyde Dehydrog.

PHA biosynthesis

 

Deinococcus-Thermus: 2

 

type 4

  

ADH short, SCP

Hormone biosynthesis

 

Fusobacteria: 2

      
 

Spirochaetes: 2

      
 

Acidobacteria: 1

      
 

Planctomycetes: 1

      
 

Viridiplantae: 1

      

32

Proteobacteria: 23

NodN-like

Nodulation protein N

P25200

 

None

Nodule formation

 

Actinobacteria: 5

      
 

Bacteroidetes: 2

      
 

Deinococcus-Thermus: 1

      
 

Spirochaetes: 1

      

102

Proteobacteria: 70

YbgC-like

YbgC protein

P44679

 

None

Cell envelope maintenance?

 

Firmicutes: 14

      
 

Cyanobacteria: 6

      
 

Archaea: 3

      
 

Actinobacteria: 2

      
 

Planctomycetes: 2

      
 

Spirochaetes: 2

      
 

Aquificae: 1

      
 

Deinococcus-Thermus: 1

      
 

Metazoa: 1

      

77

Proteobacteria: 36

FabA-like dehydratases/ synthases

β-hydroxydecanoyl ACP dehydratase (FabA)

P18391

4.2.1.60

None

Unsaturated fatty acid biosynthesis

 

Actinobacteria: 26

 

Omega-3 polyunsaturated fatty acid synthase (pfaC)

Q93CG6

 

2 × HotDog, various numbers of BKAS N-term, BKAS-C-term & Acyl-transf. in Q93CG6, Q8YWH0, and Q9S1Z9

Polyunsaturated fatty acid biosynthesis

 

Fungi: 13

 

Fatty acid synthase

Q48926

 

Acyl-transf., BKAS-N & BKAS-C

Fatty acid biosynthesis

 

Cyanobacteria: 1

      
 

Stramenopiles: 1

      

73

Viridiplantae: 57

Fat subfamily

FatA acyl-ACP-thioesterase

Q43718

3.1.2.14

None

Fatty acid synthesis

 

Firmicutes: 15

 

FatB acyl-ACP-thioesterase

Q41634

3.1.2.14

None

Fatty acid synthesis

 

Bacteroidetes: 1

      

66

Proteobacteria: 31

TesB-like

E. coli acyl-CoA thioesterase II (tesB)

P23911

3.1.2.-

2 × HotDog, cNMP in Q8GYW7

Fatty acid metabolism

 

Actinobacteria: 14

      
 

Metazoa: 14

 

Human thioesterase II/ Peroxisomal acyl-CoA thioesterase

O15261

3.1.2.2

2 × HotDog

Fatty acid metabolism. Role in HIV infection?

 

Viridiplantae: 4

      
 

Fungi: 3

      

59

Proteobacteria: 30

4HBT-II

4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU and TM1

Q04416

 

HAD domain in Q89YN2

4-chlorobenzoate degradation

 

Firmicutes: 12

      
 

Actinobacteria: 11

 

ComA2 protein

P14205

 

None

Unknown

 

Bacteroidetes: 2

      
 

Viridiplantae: 2

      
 

Chlorobi: 1

      
 

Deinococcus-Thermus: 1

      

21

Firmicutes: 21

CBS-associated

Hypothetical protein bh3175

Q9K832

 

DRTGG, 2 × CBS

Unknown

19

Proteobacteria: 10

PaaI

Phenylacetic acid degradation protein I

P76084

 

None

Phenylacetic acid metabolism

 

Archaea: 5

      
 

Actinobacteria: 2

      
 

Bacteroidetes: 1

      
 

Firmicutes: 1

      

14

Proteobacteria: 8

Hydroxyacyl-CoA dehydrogenase-associated

A. tumefaciens C58 3-hydroxyacyl-CoA dehydrogenase

Q8UJY0

 

3HCDH_N, 3HCDH in Q8UJY0 and Q92NF5

Fatty acid metabolism

 

Firmicutes: 5

      
 

Actinobacteria: 1

      

13

Proteobacteria: 10

Acetyltransferase

E. coli YiiD protein

P32148

 

acetyltransf

Putative acetyltransferase

 

Chlorobi: 1

      
 

Cyanobacteria: 1

      
 

Metazoa: 1

      

11

Firmicutes: 11

FapR

Transcription factor FapR

Q9KA00

 

HTH

Transcriptional regulation of fatty acid metabolism

11

Metazoa: 10 Proteobacteria: 1

MSCP

Mesenchymal stem cell protein DSCD75

Q9NYI2

 

None

Unknown

10

Proteobacteria: 10

YbaW

Hypothetical protein ybaW

P77712

 

None

Unknown

9

Proteobacteria: 9

AMP-binding subfamily

Hypothetical protein RSp0367

Q8XSV0

 

2 × AMP-bind

Unknown

5

Proteobacteria: 4 Firmicutes: 1

4HBT-I

4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. strain CBS-3 and DJ-12

P56653

3.1.2.23

None

4-chlorobenzoate degradation

   

Gentisyl-CoA thioesterase

Q9KBC9

 

None

Degradation of aromatic compounds?

Back to article page

BMC Bioinformatics

ISSN: 1471-2105

Contact us