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Table 1 Classifying the HotDog superfamily into subfamilies.

From: The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases

Number of Members Phyletic distribution Subfamily Name Representative member(s) Accession Number E.C. number Associated Domain(s) General Function
135 Proteobacteria : 67 Acyl-CoA thioesterases Cytosolic long-chain acyl-CoA thioester hydrolase/ Brain acyl-CoA hydrolase Q64559 3.1.2.2 2 × HotDog Fatty acid metabolism
  Metazoa: 25       
  Firmicutes: 16       
  Archaea: 9       
  Actinobacteria: 7   Cytoplasmic acetyl-CoA hydrolase (including brown fat inducible thioesterase) Q8WYK0 3.1.2.1 2 × HotDog, START Fatty acid metabolism
  Chlamydiae: 4       
  Viridiplantae: 2       
  Fungi: 2       
  Deinococcus-Thermus: 2   Acyl-CoA hydrolase Q81EE4 3.1.2.20 None Fatty acid metabolism
  Chlorobi: 2   Probable medium chain acyl-CoA hydrolase Q7NUH6 3.1.2.19 None Fatty acid metabolism
130 Proteobacteria: 61 FabZ-like Dehydratases (3R)-hydroxymyristoyl – (acyl-carrier-protein) dehydratase/ β-hydroxy-acyl ACP dehydratase (FabZ) P94584 4.2.1.58 Lpx C in Q8KBX0 Fatty acid biosynthesis, lipid A biosynthesis (Q8KBX0)
  Firmicutes: 36       
  Cyanobacteria: 9       
  Chlamydiae: 4   Coronafacic acid (CFA) dehydratase P72238 4.2.1- None CFA biosynthesis
  Alveolata: 4       
  Viridiplantae: 4       
  Planctomycetes: 3       
  Bacteroidetes: 2       
  Fusobacteria: 2       
  Aquificae: 1       
  Chlorobi: 1       
  Deinococcus-Thermus: 1       
  Metazoa: 1       
  Thermotogae: 1       
122 Proteobacteria: 81 MaoC dehydratase-like (R) specific enoyl-CoA hydratase (phaJ) Q8KRE2 4.2.1.- None PHA biosynthesis
  Firmicutes: 13   PHA synthase (phaC) O32472    
  Archaea: 11   MaoC protein P77455   None PHA biosynthesis
  Actinobacteria: 8   17-beta-hydroxysteroid dehydrogenase P51659   Aldehyde Dehydrog. PHA biosynthesis
  Deinococcus-Thermus: 2   type 4    ADH short, SCP Hormone biosynthesis
  Fusobacteria: 2       
  Spirochaetes: 2       
  Acidobacteria: 1       
  Planctomycetes: 1       
  Viridiplantae: 1       
32 Proteobacteria: 23 NodN-like Nodulation protein N P25200   None Nodule formation
  Actinobacteria: 5       
  Bacteroidetes: 2       
  Deinococcus-Thermus: 1       
  Spirochaetes: 1       
102 Proteobacteria: 70 YbgC-like YbgC protein P44679   None Cell envelope maintenance?
  Firmicutes: 14       
  Cyanobacteria: 6       
  Archaea: 3       
  Actinobacteria: 2       
  Planctomycetes: 2       
  Spirochaetes: 2       
  Aquificae: 1       
  Deinococcus-Thermus: 1       
  Metazoa: 1       
77 Proteobacteria: 36 FabA-like dehydratases/ synthases β-hydroxydecanoyl ACP dehydratase (FabA) P18391 4.2.1.60 None Unsaturated fatty acid biosynthesis
  Actinobacteria: 26   Omega-3 polyunsaturated fatty acid synthase (pfaC) Q93CG6   2 × HotDog, various numbers of BKAS N-term, BKAS-C-term & Acyl-transf. in Q93CG6, Q8YWH0, and Q9S1Z9 Polyunsaturated fatty acid biosynthesis
  Fungi: 13   Fatty acid synthase Q48926   Acyl-transf., BKAS-N & BKAS-C Fatty acid biosynthesis
  Cyanobacteria: 1       
  Stramenopiles: 1       
73 Viridiplantae: 57 Fat subfamily FatA acyl-ACP-thioesterase Q43718 3.1.2.14 None Fatty acid synthesis
  Firmicutes: 15   FatB acyl-ACP-thioesterase Q41634 3.1.2.14 None Fatty acid synthesis
  Bacteroidetes: 1       
66 Proteobacteria: 31 TesB-like E. coli acyl-CoA thioesterase II (tesB) P23911 3.1.2.- 2 × HotDog, cNMP in Q8GYW7 Fatty acid metabolism
  Actinobacteria: 14       
  Metazoa: 14   Human thioesterase II/ Peroxisomal acyl-CoA thioesterase O15261 3.1.2.2 2 × HotDog Fatty acid metabolism. Role in HIV infection?
  Viridiplantae: 4       
  Fungi: 3       
59 Proteobacteria: 30 4HBT-II 4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU and TM1 Q04416   HAD domain in Q89YN2 4-chlorobenzoate degradation
  Firmicutes: 12       
  Actinobacteria: 11   ComA2 protein P14205   None Unknown
  Bacteroidetes: 2       
  Viridiplantae: 2       
  Chlorobi: 1       
  Deinococcus-Thermus: 1       
21 Firmicutes: 21 CBS-associated Hypothetical protein bh3175 Q9K832   DRTGG, 2 × CBS Unknown
19 Proteobacteria: 10 PaaI Phenylacetic acid degradation protein I P76084   None Phenylacetic acid metabolism
  Archaea: 5       
  Actinobacteria: 2       
  Bacteroidetes: 1       
  Firmicutes: 1       
14 Proteobacteria: 8 Hydroxyacyl-CoA dehydrogenase-associated A. tumefaciens C58 3-hydroxyacyl-CoA dehydrogenase Q8UJY0   3HCDH_N, 3HCDH in Q8UJY0 and Q92NF5 Fatty acid metabolism
  Firmicutes: 5       
  Actinobacteria: 1       
13 Proteobacteria: 10 Acetyltransferase E. coli YiiD protein P32148   acetyltransf Putative acetyltransferase
  Chlorobi: 1       
  Cyanobacteria: 1       
  Metazoa: 1       
11 Firmicutes: 11 FapR Transcription factor FapR Q9KA00   HTH Transcriptional regulation of fatty acid metabolism
11 Metazoa: 10 Proteobacteria: 1 MSCP Mesenchymal stem cell protein DSCD75 Q9NYI2   None Unknown
10 Proteobacteria: 10 YbaW Hypothetical protein ybaW P77712   None Unknown
9 Proteobacteria: 9 AMP-binding subfamily Hypothetical protein RSp0367 Q8XSV0   2 × AMP-bind Unknown
5 Proteobacteria: 4 Firmicutes: 1 4HBT-I 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. strain CBS-3 and DJ-12 P56653 3.1.2.23 None 4-chlorobenzoate degradation
    Gentisyl-CoA thioesterase Q9KBC9   None Degradation of aromatic compounds?