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Figure 6 | BMC Bioinformatics

Figure 6

From: MUSCLE: a multiple sequence alignment method with reduced time and space complexity

Figure 6

Neighbor-joining and UPGMA trees for progressive alignment. Here we show the same set of four sequences and the order in which they will be aligned according to a neighbor-joining tree (above) and a UPGMA tree (below). Notice that t and u are the most closely related pair, but (s, t) and (u, v) are evolutionary neighbors. With neighbor joining, t and u are not aligned to each other until the root, in contrast to UPGMA, which aligns s and t as the first pair.

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