Artificial neural network approach for selection of susceptible single nucleotide polymorphisms and construction of prediction model on childhood allergic asthma

Table 6 Two-SNP interactions among the 10 selected SNPs (P-value < 0.05 and ECV2 < 0.5)

SNP 1	SNP 1 genotype	SNP 2	P ^a	P ^b	P ^c	P^b × P^c	P^a/(P^b × P^c)
C 3 (4896 C/T)	TT	C 3 (1692 G/A)	0.01461	0.7205	0.6993	0.5038	0.0290
CysLT2 (2534 A/G)	AG+GG	IL-4Rα (148 G/A)	0.00030	0.5664	0.0155	0.0088	0.0344
C 3 (1692 G/A)	AA	C 3 (4896 C/T)	0.02858	0.6993	0.7205	0.5038	0.0567
C 3 (912 G/A)	GG	C 3 (4896 C/T)	0.02345	0.5020	0.7205	0.3617	0.0648
C 3 (4896 C/T)	TT	C 3 (912 G/A)	0.03073	0.7205	0.5020	0.3617	0.0850
C 3 (1692 G/A)	GA	CysLT2 (2534 A/G)	0.04917	0.6993	0.5664	0.3961	0.1241
STAT6 (2964 G/A)	GG+GA	IL-10 (-571 C/A)	0.01752	0.7881	0.1074	0.0846	0.2070
C 3 (4896 C/T)	TT	IL-4Rα (148 G/A)	0.00271	0.7205	0.0155	0.0112	0.2426
C 3 (912 G/A)	GG	IL-4Rα (148 G/A)	0.00345	0.5020	0.0155	0.0078	0.4442
IL-4 (-590 C/T)	CT+TT	IL-4Rα (148 G/A)	0.00689	0.9085	0.0155	0.0141	0.4896

^aP-value of combination of SNP 2 with genotype consisting of SNP 1. In this case, D.F. of SNP 2 is identical to that of Table 1.
^bP-value of SNP 1 calculated alone.
^cP-value of SNP 2 calculated alone.
^a P ^/(b P ^{× c} P ^{) represents effective combination value (ECV2).}

ISSN: 1471-2105