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Table 1 Methods of summarizing data. The effects of pooling and reduction to proportions on a single tag measured across four libraries. Pooling reduces the data to the summed counts at the right, and focusing on proportions reduces the data to the proportions on the bottom. In both cases, information is lost.

From: Overdispersed logistic regression for SAGE: Modelling multiple groups and covariates

      Summed Counts
Tag Count Y 1 Y 2 Y 3 Y 4
Library Size n 1 n 2 n 3 n 4
Proportions Y1/n1 Y2/n2 Y3/n3 Y4/n4