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Table 3 Retrospective study of the predictive capability of the "hypothetical relationships" generated by Chilibot

From: Content-rich biological network constructed by mining PubMed abstracts

Term 1 Tertiary nodes Term 2 References Analyzed Relationship Documented
LTP PI-3K PKA CAMKII ACTIN ERK TAU PKC AMPA KV4.2 1960~2000 2001~2004
LTP PKA ACTIN SYNAPTOPHYSIN PKC NMDA TAU AMPA PLC ERK 1960~1995 1996~2000
LTP PKA ACTIN NMDA TAU AMPA PLC ARC 1960~1995 1996~2000
LTP PKA ACTIN CREB PKC PLC PI-3K 1960~1995 1996~2000
LTP PKA ACTIN SYNAPTOPHYSIN PKC TAU ACTININ 1960~1995 1996~2000
LTP PKA CAMKII CREB PKC TAU ATF 1960~1995 1996~2000
LTP ZIF268 PKC NMDA PLC TRKB 1960~1995 1996~2000
LTP PKA CAMKII CREB CAMKIV 1960~1995 1996~2000
LTP ZIF268 PLC TRKA 1960~1995 1996~2000
LTP NMDA TAU PLC ACTIN ARC 1960~1990 1996~2000
LTP PKC TAU CAMKII ACTIN SYNAPSIN I 1960~1990 1991~1995
LTP PKC NMDA TAU ACTIN PKA 1960~1990 1991~1995
LTP TAU ACTIN SYNAPTOPHYSIN 1960~1990 1991~1995
LTP TAU ACTIN ACTININ 1960~1990 1996~2000
LTP ACTIN ZIF268 1960~1990 1991~1995
  1. A "hypothetical relationship" is defined when two terms have no documented relationship, but share connections to the same tertiary node(s). To test the value of these relationships in predicting the findings of future research, 22 terms (i.e., term 2; see methods) known to be involved in long-term potentiation (LTP) (i.e. term 1) were queried by Chilibot, limiting the latest references analyzed to the years 1990, 1995, 2000, and 2004. The "hypothetical relationships" (i.e. term 1 is related to term 2) and the time periods when these hypothetical relationships were suggested and documented are listed. The original results of these searches including links to the PubMed abstracts are available [see additional file 5].