Table 2 The most promiscuous compounds in the network. The frequency of a compound is the number of times the compound occurs as part of an edge in the network.
From: Network analysis of metabolic enzyme evolution in Escherichia coli
RANK | COMPOUND | FREQUENCY |
|---|---|---|
1 | H2O | 79,485 |
2 | ATP | 46,579 |
3 | H+ | 27,033 |
4 | Mg2+ | 26,384 |
5 | ADP | 23,954 |
6 | Orthophosphate | 23,189 |
7 | Pyridoxal phosphate | 10,091 |
8 | NAD | 7,710 |
9 | NADH | 5,742 |
10 | CO2 | 4,245 |
11 | Pyruvate | 4,130 |
12 | NADP | 3,638 |
13 | NADPH | 3,284 |
14 | AMP | 2,964 |
15 | NH3 | 2,692 |
16 | Coenzyme A | 2,638 |
17 | L-Glutamate | 2,302 |
18 | Acetyl-CoA | 982 |
19 | Phosphoenolpyruvate | 941 |
20 | O2 | 920 |
21 | 2-Ketoglutarate | 808 |
22 | Mn2+ | 650 |
23 | S-Adenosylmethionine | 454 |
24 | L-Aspartate | 408 |
25 | FAD | 378 |
26 | Fructose-6-phosphate | 312 |
27 | GAP | 277 |
28 | Zn2+ | 272 |
29 | Sucrose | 272 |
30 | K+ | 268 |