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Table 2 The most promiscuous compounds in the network. The frequency of a compound is the number of times the compound occurs as part of an edge in the network.

From: Network analysis of metabolic enzyme evolution in Escherichia coli

RANK COMPOUND FREQUENCY
1 H2O 79,485
2 ATP 46,579
3 H+ 27,033
4 Mg2+ 26,384
5 ADP 23,954
6 Orthophosphate 23,189
7 Pyridoxal phosphate 10,091
8 NAD 7,710
9 NADH 5,742
10 CO2 4,245
11 Pyruvate 4,130
12 NADP 3,638
13 NADPH 3,284
14 AMP 2,964
15 NH3 2,692
16 Coenzyme A 2,638
17 L-Glutamate 2,302
18 Acetyl-CoA 982
19 Phosphoenolpyruvate 941
20 O2 920
21 2-Ketoglutarate 808
22 Mn2+ 650
23 S-Adenosylmethionine 454
24 L-Aspartate 408
25 FAD 378
26 Fructose-6-phosphate 312
27 GAP 277
28 Zn2+ 272
29 Sucrose 272
30 K+ 268