Network analysis of metabolic enzyme evolution in Escherichia coli

BMC Bioinformatics

Table 3 The enzymes with the highest connectivities (k) of the network for the whole and the reduced networks. The connectivity of an enzyme is here defined as the number of enzymes which it is connected to by an outgoing edge.

	WHOLE NETWORK		REDUCED NETWORK
RANK	ENZYME	K	ENZYME	K
1	Carbamoyl phosphate synthase	735	Taurine dioxygenase	61
2	ATP synthase	704	Aspartate transaminase	57
3	Phosphoenolpyruvate synthase	604	Isocitrate dehydrogenase	56
4	S-adenosylmethionine synthetase I	603	Malate oxidase	53
5	NAD+ synthase	599	Quinolinate synthetase	48
6	NADP phosphatase	583	Alpha-galactosidase	46
7	Asparagine synthase B	578	3-dimethylubiquinone 3-methyltransferase	46
8	Selenophosphate synthase	563	Transketolase I	45
9	Methionine adenosyltransferase 2	558	Fructose 1,6-bisphosphatase II	45
10	Mg²⁺-importing ATPase	558	Glutamate synthase (NADPH)	45

ISSN: 1471-2105