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Table 3 The enzymes with the highest connectivities (k) of the network for the whole and the reduced networks. The connectivity of an enzyme is here defined as the number of enzymes which it is connected to by an outgoing edge.

From: Network analysis of metabolic enzyme evolution in Escherichia coli

  WHOLE NETWORK REDUCED NETWORK
RANK ENZYME K ENZYME K
1 Carbamoyl phosphate synthase 735 Taurine dioxygenase 61
2 ATP synthase 704 Aspartate transaminase 57
3 Phosphoenolpyruvate synthase 604 Isocitrate dehydrogenase 56
4 S-adenosylmethionine synthetase I 603 Malate oxidase 53
5 NAD+ synthase 599 Quinolinate synthetase 48
6 NADP phosphatase 583 Alpha-galactosidase 46
7 Asparagine synthase B 578 3-dimethylubiquinone 3-methyltransferase 46
8 Selenophosphate synthase 563 Transketolase I 45
9 Methionine adenosyltransferase 2 558 Fructose 1,6-bisphosphatase II 45
10 Mg2+-importing ATPase 558 Glutamate synthase (NADPH) 45