Figure 3

Molecular events shown by associated predicates. The figure shows a hypothetical signal transduction pathway of an idealized cell. The signal is triggered at the outer membrane ligand-binding to receptor dimers. This signal is mediated (by various proteins) to the nucleus of the cell using various events (protein-protein interactions, phosphorylation etc.) and initiates transcription of a gene. The protein product (after splicing, translation and synthesis) of the gene inhibits receptor signaling. Thus, it regulates its own expression levels via a negative feedback loop. The direction of information flow is shown with arrows. Cell compartments, molecular entities and predicates describing various events are shown. The predicates analyzed in this work aim to cover events in gene expression, regulation and signaling processes.