Figure 7
From: Modeling of cell signaling pathways in macrophages by semantic networks
A SN- simulator: at the end of the simulation. The pathway-viewer shows that the initial translocation of the IgG molecule has led to the occurrence of a series of events, which include several non-covalent interactions, covalent interactions, and translocations of various molecules: Event #1: the IgG was translocated from the extracellular space to the plasma membrane. Event #2: the IgG bound to the Fcγ receptor at the plasma membrane. Event #3: the Lyn was translocated from the cytosol to the plasma membrane. Event #4: the Lyn bound to the Fcγ receptor at the plasma membrane. Event #5: the Lyn phosphorylated the Gab2 to a Gab2-phosphate (Gab2-P) at the plasma membrane. Event #6: the PI3K-p85 and p110 (already bound to each other) were translocated together from the cytosol to the plasma membrane. Event #7: the PI3K-p85 bound to the Gab2-P at the plasma membrane. Event #8: the PI3K-p110 phosphorylated the PIP2 to a PIP3 (PI[3,4,5]P3) at the plasma membrane. Event #9: The formation of the PIP3 caused phagosome formation.