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Table 2 Classification of biological events in 5 prototypes in the semantic network.

From: Modeling of cell signaling pathways in macrophages by semantic networks

Semantic Agent – Event

Biological Example

Translocation

A protein moves from cytosol to plasma membrane.

Non-covalent Interaction

A ligand binds to a receptor.

Covalent Interaction

An enzyme catalyzes a chemical reaction where substrates are converted to products.

Allosteric Regulation

A ligand binding on site A of a protein causes a conformational change on site B of the protein.

Cellular Response

Cell survival, cell death, phagosome formation, increase of intracellular glucose level.