Implications for domain fusion protein-protein interactions based on structural information

BMC Bioinformatics

Table 1 List of domain pairs separated by less than 30 residues but are not interacting

Domain 1	Molecular Function	Domain 2	Molecular Function	No. of Contacts
2-Hacid_DH	oxidoreductase activity	2-Hacid_DH_C	oxidoreductase activity	4
CH		CH		0
Cytochrome_CIII		Cytochrome_CIII		0
dsrm	double-stranded RNA binding	dsrm	double-stranded RNA binding	0
EGF		EGF		0
eRF1_l		eRFl_2		0
FKBP		FKBP		1
fnl		fnl		0
fnl		fn2		2
fn2		fn2		0
GlutR_NAD_bind	glutamyl-tRNA reductase activity	GlutR_dimer	glutamyl-tRNA reductase activity	1
HTH_9	molybdate ion transporter activity	TOBE		0
kazal		kazal		0
MHC_II_beta	immune response	ig		2
myb_DNA-binding	DNA binding	myb_DNA-binding	DNA binding	0
Peptidase_M10	proteolysis and peptidolysis	fn2		2
Phe_tRNA-synt_N	phenylalanine-tRNA ligase activity	tRNA-synt_2d	phenylalanine-tRNA ligase activity;	0
resolvase	recombinase activity ;DNA recombination	HTH_7	recombinase activity;DNA recombination	1
RHD	regulation of transcription, DNA-dependent	TIG		0
Ribosomal_L9_N	structural constituent of ribosome	Ribosomal_L9_C	structural constituent of ribosome	0
RNase_PH_C	RNA binding;RNA processing	KH	nucleic acid binding	0
Rotamase	isomerase activity	Rotamase rrm	isomerase activity	0
rrm		rrm		4
rve	DNA binding ;DNA recombination	integrase	integrase activity	0
SH2	intracellular signaling cascade	SH3		0
sushi		sushi		4
TPP_enzymes_N		TPP_enzymes		2
WW		WW		0
zf-Sec23_Sec24		Sec23_trunk		0

ISSN: 1471-2105