TY - JOUR AU - Gagneur, Julien AU - Klamt, Steffen PY - 2004 DA - 2004/11/04 TI - Computation of elementary modes: a unifying framework and the new binary approach JO - BMC Bioinformatics SP - 175 VL - 5 IS - 1 AB - Metabolic pathway analysis has been recognized as a central approach to the structural analysis of metabolic networks. The concept of elementary (flux) modes provides a rigorous formalism to describe and assess pathways and has proven to be valuable for many applications. However, computing elementary modes is a hard computational task. In recent years we assisted in a multiplication of algorithms dedicated to it. We require a summarizing point of view and a continued improvement of the current methods. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-5-175 DO - 10.1186/1471-2105-5-175 ID - Gagneur2004 ER -