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Table 2 Comparison of different cutoff independent approaches. The top ten categories and their corresponding ranks for each of the the four methods: Wilcoxon rank sum (WRS) with sample label permutation null hypothesis (s.l.p.), WRS with gene permutation null hypothesis (g.p.), the Kolmogorov-Smirnov score (K-S) as used in GSEA [17], and the minimal cutoff-based p-value (min-p) [7, 8]. Percentile columns indicate the position of the 25th, 50th and 75th percentile in the ranked gene list which comprises 5224 genes and is based on the data set of van't Veer et al.. The last column indicates the number of genes in each category. The full table is available as a supplementary file [see Additional file 3].

From: Comparing functional annotation analyses with Catmap

GoName

GoId

WRS

K-S

min-p

25%

50%

75%

#genes

  

s.l.p.

g.p.

      

carbon-nitrogen ligase act..

0016884

1

7

53

16

6

6

27

2

spindle microtubule

0005876

2

13

54

19

38

38

42

2

organic acid metabolism

0006082

3

9

11

8

564

1619

3283

83

carboxylic acid metabolism

0019752

4

8

12

7

564

1619

3283

83

intramolecular isomerase act..

0016863

5

10

10

12

195

412

453

4

deoxynucleoside kinase act..

0019136

6

18

60

51

70

70

117

2

GMP synthase activity

0003921

7

27

317

78

6

6

6

1

intramolecular isomerase act..

0016860

9

12

9

14

195

453

905

9

biotin metabolism

0006768

10

21

62

58

76

76

132

2

nucleus

0005634

71

16

28

10

1100

2353

3797

574

mitotic cell cycle

0000278

121

1

3

1

346

1419

3031

93

M phase

0000279

107

2

1

2

251

848

1862

41

nuclear division

0000280

124

3

2

3

251

867

1862

40

M phase of mitotic cell cycle

0000087

130

4

4

4

238

848

1862

36

mitosis

0007067

152

5

5

5

235

848

1862

35

cell cycle

0007049

142

6

6

6

731

1689

3599

172

cell proliferation

0008283

112

11

7

9

891

1947

3645

264

regulation of cell cycle

0000074

153

29

8

15

731

1689

3604

105