Figure 5

Correctly mapped domain with large insertion: monomeric isocitrate dehydrogenase. a) Ribbon diagram of monomeric isocitrate dehydrogenase from Azotobacter vinelandii (PDB: 1itw[29]). The insert region as defined by SCOP is shown in grey. b) Ribbon diagram of isopropylmalate dehydrogenase from Salmonella typhimurium (PDB: 1cnz[30]), a library representative of the isocitrate/isopropylmalate dehydrogenase superfamily. c) Range assignments as made by MAMMOTH, DaliLite, and SCOP. The regions assigned to the isocitrate/isopropylmalate dehydrogenase superfamily are red and insert regions are grey.